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Tuesday, July 14, 2020 | History

2 edition of Effects of transient global ischemia on distribution and phosphorylation of the [alpha]-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors at the synapse. found in the catalog.

Effects of transient global ischemia on distribution and phosphorylation of the [alpha]-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors at the synapse.

Damanpreet Bawa

Effects of transient global ischemia on distribution and phosphorylation of the [alpha]-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors at the synapse.

by Damanpreet Bawa

  • 184 Want to read
  • 39 Currently reading

Published .
Written in English


About the Edition

alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are implicated in ischemia-induced neuronal death. We investigated the effects of global ischemia on distribution and phosphorylation of synaptic AMPARs in lipid rafts (DRMs), post-synaptic densities (PSDs) and extra-synaptic membranes (detergent soluble fraction) at various recovery times. We determined that 0.5% Triton X-100 (TX-100) with 1:1 detergent to protein ratio was the preferred condition to isolate post-synaptic DRMs. After ischemia, following an initial decrease there was a trend towards increase in synaptic AMPARs by 24 hours. AMPARs increased in PSDs at 6 hours in forebrain and hippocampus. GluR1 phosphorylation at Ser-831 decreased in DRMs and PSDs at 24 hours. Ser-845 showed increase in PSDs and transient changes in DRM and soluble fractions. Increased synaptic GluR1 is consistent with increased Ser-845 phosphorylation. The findings suggest that different synaptic populations of AMPARs are regulated differently after ischemia and lipid rafts may be involved in regulating AMPAR distribution.

The Physical Object
Pagination189 leaves.
Number of Pages189
ID Numbers
Open LibraryOL19216125M
ISBN 10049407096X


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Effects of transient global ischemia on distribution and phosphorylation of the [alpha]-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors at the synapse by Damanpreet Bawa Download PDF EPUB FB2